The Evidence Behind Our Practice
Our physicians do not only practice apheresis — they publish, edit, and present the research that defines the field. Below is the peer-reviewed work behind the care we deliver.
A Guest-Edited Journal Issue
Transfusion and Apheresis Science · 2026;65(4)
Therapeutic Apheresis: Novel Indications & Emerging Technologies
Dr. Dobri Kiprov and Dr. Allen Green served as guest editors of this five-article theme issue, mapping the transition from apheresis as a rescue intervention toward precision apheresis across neurodegeneration, post-infectious immune dysregulation, cardiovascular and renal disease, and selective adsorption technology.
Peer-Reviewed Publications
Key publications from over 100 peer-reviewed works spanning four decades of advancing therapeutic apheresis.
Fuentealba M, Kiprov D, Schneider K, Mu WC, Kumaar PA, Kasler H, Burton JB, Watson M, Halaweh H, King CD, Yuksel ZS, Roska-Pamaong C, Schilling B, Verdin E, Furman D. “Multi-Omics Analysis Reveals Biomarkers That Contribute to Biological Age Rejuvenation in Response to Single-Blinded Randomized Placebo-Controlled Therapeutic Plasma Exchange.” Aging Cell. 2025 Aug;24(8):e70103.
View Publication →Kim D, Kiprov DD, Luellen C, et al.. “Old Plasma Dilution Reduces Human Biological Age: A Clinical Study.” GeroScience. 44, 2701-2720, 2022.
View Publication →Mehdipour M, Etienne J, Liu C, Mehdipour T, Kato C, Conboy M, Conboy I, Kiprov DD. “Attenuation of Age-Elevated Blood Factors by Repositioning Plasmapheresis: A Novel Perspective and Approach.” Transfus Apher Sci. 2021 Jun;60(3):103162.
View Publication →Kiprov D. “Therapeutic Plasma Exchange (TPE) and Blood Products — Implications for Longevity and Disease.” Transfus Apher Sci. 2021 Jun;60(3):103163.
View Publication →Mehdipour M, Skinner C, Wong N, Lieb M, Liu C, Etienne J, Kato C, Kiprov D, Conboy MJ, Conboy IM. “Rejuvenation of Three Germ Layers Tissues by Exchanging Old Blood Plasma with Saline-Albumin.” Aging (Albany NY). 12, 8790-8819, 2020.
View Publication →Kiprov D. “Intermittent Heterochronic Plasma Exchange as a Modality for Delaying Cellular Senescence — A Hypothesis.” J Clin Apheresis. 28:387-389, 2013.
View Publication →Boada M, Kiprov D, Anaya F, Lopez OL, Nunez L, Olazaran J, Lima J, Grifols C, Barcelo M, Rohe R, Prieto-Fernandez C, Szczepiorkowski ZM, Paez A. “Feasibility, Safety, and Tolerability of Two Modalities of Plasma Exchange with Albumin Replacement to Treat Elderly Patients with Alzheimer’s Disease in the AMBAR Study.” J Clin Apher. 2023 Feb;38(1):45-54.
View Publication →Boada M, Lopez OL, Olazaran J, Nunez L, Pfeffer M, Puente O, Pinol-Ripoll G, Gamez JE, Anaya F, Kiprov D, Alegret M, Molina-Porcel L, Bozzo J, Szczepiorkowski ZM, Hendrix S, Paez A. “Neuropsychological, Neuropsychiatric, and Quality-of-Life Assessments in Alzheimer’s Disease Patients Treated with Plasma Exchange with Albumin Replacement from the Randomized AMBAR Study.” Alzheimer’s and Dementia. 2021.
View Publication →Boada M, Lopez O, Nunez L, Olazaran J, Pfeffer M, Paricio M, Lorites J, Pinol G, Gamez J, Anaya F, Ortiz P, Kiprov D, Grifols C, Torres M, Costa M, Bozzo J, Szczepiorkowski Z, Hendrix S, Paez A. “A Randomized Controlled Clinical Trial of Plasma Exchange with Albumin Replacement for Alzheimer’s Disease: Primary Results of the AMBAR Study.” Alzheimer’s and Dementia. June 4, 2020.
View Publication →Kiprov DD, Herskowitz A, Kim D, Lieb M, Liu C, Watanabe E, Hoffman JC, Rohe R, Conboy MJ, Conboy IM. “Case Report: Therapeutic and Immunomodulatory Effects of Plasmapheresis in Long-Haul COVID.” F1000Res. 2021 Nov 24;10:1189.
View Publication →Kiprov D, Conboy MJ, Conboy IM. “Immunomodulation for the Management of Corona Virus Disease (COVID-19).” Transfus. Apher. Sci.. 59, 102856, 2020.
View Publication →Kiprov D, Hanson C, Sheppard H. “Alloimmunization to Prevent AIDS?.” Science. vol. 263, p. 737, February 1994.
Mitterman A, Bertram D, Snyder H, Messerschmidt G, Diavarella D, Ainsworth S, Kiprov D, Arlin Z. “Treatment of Patients with HIV Thrombocytopenia and Hemolytic Uremic Syndrome with Protein A (Prosorba Column) Immunoadsorption.” Seminars in Hematology. 1989, 26:15-18.
Kiprov D, Pfaeffl W, Parry G, Lang W, Miller R. “Antibody-Mediated Peripheral Neuropathies Associated with ARC and AIDS: Successful Treatment with Plasmapheresis.” J Clin Aphere. 4:3-7, 1988.
Kiprov D, Lippert R, et al.. “Antilymphocyte Antibodies and Seronegative Hemophiliacs.” New England J. of Med.. 313:1514-1515, 1985.
Kiprov D, Simpson DM, et al.. “Use of Staphylococcal Protein A Immunoadsorption Column in Treating Immune-Mediated Disease.” J Biol Response Modifiers. 3:330-346, 1985.
Lipkin I, Parry G, Kiprov D, et al.. “Inflammatory Neuropathy in Homosexual Men with Lymphadenopathy.” Neurology. 35:1479-1483, 1985.
Abrams D, Kiprov D, Volberding P. “Isolated Thrombocytopenia in Homosexual Men — Longitudinal Follow-up.” AIDS-Associated Syndromes: Advances in Experimental Medicine and Biology. 187:117-122, 1985.
Kiprov D, Miller R. “Polymyositis Associated with Benign Monoclonal Gammopathy.” Lancet. II: 1183-1186, 1984.
Kiprov D, Morand P. “The Effect of Plasmapheresis and Immunosuppressive Drug Therapy on T-Cell Subsets as Defined by Monoclonal Antibodies.” J Clin Aphere. 1-57, 1983.
Kiprov D, Colvin R, McCluskey R. “Focal and Segmental Glomerulosclerosis and Proteinuria Associated with Unilateral Renal Agenesis.” Lab Invest. 46:275, 1982.
Recent Presentations
Invited talks bringing apheresis research to the regenerative medicine and longevity communities.
Global Longevity Federation 2026
Rome, Italy · March 2026
Therapeutic plasma exchange for healthspan extension
Presented by Dobri D. Kiprov, MD, HP
Read the Recap →WIRM World Congress 2026
San Francisco, California · April 2026
Plasmapheresis and therapeutic plasma exchange
Presented by Dobri D. Kiprov, MD, HP
Read the Recap →Following the meetings we attend? Read our conference coverage on the blog →